atrial fibrillation
Conditions
Interventions
Groups without atrial fibrillation.:No intervention
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Mitral valve replacement or plastic heart surgery under elective cardiopulmonary bypass in our hospital with ASA grade II-III and age greater than or equal to 18 years; (2) Left ventricular ejection fraction (LVEF>35%); (3) Willing to sign informed consent and complete all research content.
Exclusion criteria
Exclusion criteria: (1) Patients aged 18 years or less; (2) Degree of carotid artery stenosis >50% or have significant plaque; (3) Second thoracotomy or emergency surgery; (4) Preoperative echocardiography indicated obvious aortic valve lesions; (5) diabetes mellitus, coronary heart disease, active period of rheumatism, acute and chronic inflammatory period, autoimmune diseases, etc., and recently taking hormones, ACEI preparations, urico-lowering drugs. (6)Preoperative child-pugh classification of liver function was B or C, with serum creatinine exceeding 177 µmol/L; (7) Reject participants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Syndecan-1;HS; | — |
Secondary
| Measure | Time frame |
|---|---|
| NO;TNF-a;IL-6;sTM;vWF;Flow shear stress;Cardiopulmonary bypass time;Aortic occlusion time;Postoperative mechanical ventilation time;CCU stay time;Length of stay in general ward; | — |
Countries
china
Contacts
Public ContactWeijian Wang
Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed