Different thyroid cancer
Conditions
Interventions
Group A:100mCi 131I
Group B:150mCi 131I
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) Age=18 years old; (2) Complete total thyroidectomy, subtotal thyroidectomy or near-total thyroidectomy and cervical lymph node dissection; (3) Patients with differentiated thyroid carcinoma, including papillary carcinoma (PTC), follicular papillary carcinoma and follicular carcinoma (FTC); (4) Without the history of 131I treatment; (5) Less than 6 months between the completion of thyroid surgery and the initial 131I treatment ; (6) High-risk patients who meet one of the following criteria in the 2015 ATA guidelines; 1) Macroscopic treatment of perithyroid invasion (extensive extra-thyroid invasion); 2) Residual tumor; 3) The pathological stage was N1, with the maximum diameter of any lymph node =3cm; 4) Extensive vascular invasion of FTC (>4 lesions) (7) Thyroglobulin (s-Tg) level in stimulated state = 5ng/ml; (8) ECOG physical status 0 or 1 score.
Exclusion criteria
Exclusion criteria: (1) Partial thyroidectomy; (2) The histological types were medullary thyroid carcinoma, undifferentiated carcinoma, Hurtle cells, aggressive histological types (high cells, shoe spikes or columnar cells); (3) Patients with distant metastasis at first diagnosis (M1); (4) Thyroglobulin (s-Tg) level > 5ng/ml under stimulation; (5) Patients with incomplete surgical and postoperative pathological data could not accurately stratify risk; (6) Patients with other malignant tumors or a history of malignant tumors; (7) Have a history of serious heart, liver, lung, kidney dysfunction and other systemic multiple organ system function impairment; (8) Pregnant patients (regardless of gender), pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Thyroglobulin; | — |
Countries
China
Contacts
Public ContactLin Li
West China Hospital of Sichuan University
Outcome results
None listed