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Observation of the therapeutic effect of Guasha on motor and non-motor symptoms in Parkinson's Disease Patients

Exploring the mechanism of Guasha on the neuroinflammation of Parkinson's disease based on the Transmission Pathway of plasma exosome anti-inflammatory factors across the blood-brain barrier

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400081899
Enrollment
Unknown
Registered
2024-03-14
Start date
2024-03-15
Completion date
Unknown
Last updated
2024-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease

Interventions

the control group:Exclusive pharmacological treatment. Based on the condition, patients of the control group were given exclusive Western medication treatment, with each patient taking =3 types of ora
the Observation Group:Gua Sha combined with Western medication treatment. The Western medication treatment method is the same as that of the control group, and the specific Gua Sha method is described

Sponsors

Nanjing Hospital of traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Meets the Western medical diagnostic criteria for Parkinson's Disease (PD); 2. Syndrome differentiation according to Traditional Chinese Medicine (TCM) standards; 3. Hoehn-Yahr staging = 2.5; 4. Disease duration of = 1 year; 5. Exclusive pharmacological treatment for PD with no more than two types of medications, with a stable dosage for = 30 days; 6. Voluntary participation with informed consent; 7. Good compliance and willing to cooperate with follow-up.

Exclusion criteria

Exclusion criteria: 1. Individuals with contraindications to Gua Sha, such as a tendency to bleed, blood system diseases, infectious skin diseases, extreme hunger or satiety, excessive thinness, or excessive fatigue; 2. Those who have undergone deep brain stimulation surgery; 3. Patients with severe brain, heart, liver, kidney, lung, or hematopoietic system diseases, and those with malignant tumors; 4. Individuals with mental disorders; 5. Those who are currently participating in or have participated in another clinical trial within the past 30 days.

Design outcomes

Primary

MeasureTime frame
Movement Disorder Society-Unified Parkinson’s Disease rating scale (MDS-UPDRS) score;Timed Up and Go Test (TUGT);Non-motor Symptoms Scale (NMSS) score;Plasma Inflammatory Cytokines;Therapeutic Efficacy Evaluation;

Secondary

MeasureTime frame
Parkinson’s disease Sleep Scale 2nd Version (PDSS-2) score;constipation scoring system (CSS) score;King’s Parkinson’s disease pain scale (KPPS) score;Parkinson Fatigue Scale (PFS-16) score;Hamilton Rating Scale for Anxiety (HAMA) score;24-item Hamilton Depression Scale (HAMD-24) score;the 39-item Parkinson’s Disease Questionnaire (PDQ-39) score;

Countries

China

Contacts

Public ContactWang Qiuqin

Nanjing University of Chinese medicine

qiuqin.wang@njucm.edu.cn+86 25 8581 1877

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026