Postoperative complications of the central nervous system
Conditions
Interventions
Intervention group:Intravenous infusion of 0.6µg/kg load dose of dexmedetomidine within 10 minutes after intubation, followed by continuous infusion at a rate of 0.4 µg/kg/h until 30 minutes before th
Control group:Provide equal volume of physiological saline
Sponsors
The First Medical Center, Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age range from 18 to 85 years old, regardless of gender 2. Patients who undergo cardiac surgery on a scheduled basis; 3. ASA level 1-4; 4. Obtain written informed consent form;
Exclusion criteria
Exclusion criteria: 1. Patients with MMSE scores less than 18 or dementia, intellectual disability, and inability to communicate (coma, severe dementia, hearing or language impairment); 2. Have a history of mental or neurological disorders (such as schizophrenia, epilepsy, Parkinson's disease, or severe myasthenia gravis); 3. Previous history of brain injury; 4. Severe liver dysfunction (Child pugh C-grade) or renal insufficiency (preoperative dialysis); 5. Severe bradycardia (heart rate below 50 beats per minute), pathological sinus syndrome, or atrioventricular block without a pacemaker; 6. Postoperative intensive care unit (ICU) duration exceeding 7 days or death;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative depression;The incidence of postoperative anxiety; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium;Postoperative Pain;Postoperative sleep disorders;Postoperative quality of life evaluation;Postoperative mortality rate;Surgical related complications; | — |
Countries
China
Contacts
Public ContactMi Weidong
The First Medical Center, Chinese PLA General Hospital
Outcome results
None listed