Aging and frailty
Conditions
Interventions
Exercise:Exercise training
Control:healthy lifestyle
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: non-disabled old adults aged 65 to 85 years old, who can walk 400 meters in 15 minutes without the help of another person or the assistance of a walker, and voluntarily to accept at least 1-year follow-up and a study-related exercise program.
Exclusion criteria
Exclusion criteria: 1. Acute myocardial infarction (3-5 days), unstable angina pectoris, resting electrocardiogram suggesting an acute cardiac event; 2. Active endocarditis, myocarditis, or pericarditis; 3. Uncontrolled arrhythmias causing symptoms or hemodynamic compromise, high-degree atrioventricular block without pacemaker; 4. Acute congestive heart failure or heart function Grade III-IV (New York Classification); 5. Aortic dissection, aortic aneurysm or severe valvular disease; 6. Uncontrolled asthma, pulmonary edema, significant pulmonary hypertension, or low room air desaturation at rest (=85%); 7. Other severe uncontrolled diseases (hypertension, diabetes, thyrotoxicosis, severe renal insufficiency, infection); 8. Moderate to severe cognitive dysfunction (MMSE=20), mental impairment leading to inability to cooperate; 9. Circumstances such as atrial fibrillation, frequent premature contractions, or the presence of metal implants in the chest and abdominal cavity where cardiac magnetic resonance imaging cannot be performed; 10. Difficulty communicating with the study personnel due to speech, language, hearing or visual problems; 11. Inability or unwillingness to provide informed consent or accept follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change of peak Oxygen uptake/kg; | — |
Secondary
| Measure | Time frame |
|---|---|
| changes of maximal work rate, peak oxygen uptake, anaerobic threshold, work efficiency, static ventilation function and ventilatory efficiency during exercise;changes of static cardiac structure and function;changes of geriatric assessments of function, body composition and agerelated biomarkers; | — |
Countries
China
Contacts
Public ContactPengli Zhu
Fujian Provincial Hospital
Outcome results
None listed