epilepsy
Conditions
Interventions
Experimental group 1:Real-eTNS+Basic medicine
Control group 1:Sham-eTNS+Basic medicine
Experimental group 2:Real-tVNS+Basic medicine
Control group 2:Sham-tVNS+Basic medicine
Sponsors
Xi'an Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-70 years old 2. Meet the diagnostic criteria of the 2023 guidelines for the diagnosis and treatment of epilepsy, and use =1 antiepileptic drug at the same time 3. No current medications affecting the central nervous system 4. Have had partial or tonic generalized seizures in the past two months 5. Be able and willing to cooperate with the recording of conditions (including medication regimen and seizure frequency), and cooperate with the collection of EEG and saliva samples.
Exclusion criteria
Exclusion criteria: 1. Any serious mental illness (e.g., schizophrenia or delusional disorder) 2. Brain injury with loss of consciousness or suicidal tendencies 3. Pacemaker implantation or other metal-implanted devices 4. Accompanied by progressive central nervous system disease or severe heart, liver, kidney and blood diseases 5. History of significant arrhythmia 6. A history of nonepileptic seizures 7. Presence of cardiovascular disease (e.g., arrhythmia, heart failure, or ischemic heart disease) 8. Have structural diseases (such as cortical dysplasia, brain tumors, or vascular lesions) 9. Current or previous transcutaneous electrical stimulation for less than 3 months 10. History of facial or trigeminal pain 11. Inability of the patient or family to fully adhere to the treatment regimen 12. Pregnant or planning to become pregnant 13. Those who refuse to sign the informed consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in EEG power and hemispheral coherence; | — |
Countries
China
Contacts
Public ContactZhengli Di
Xi'an Central Hospital
Outcome results
None listed