polycystic ovary syndrome (PCOS)
Conditions
Interventions
ZSY group:Start taking Letrozole on the 5th day of each menstrual cycle, 2 tablets of 5mg once daily after meal for 5 days. On top of this, Zishen Yutai Pills should be added, starting from the 5th da
control group:Start Letrozole on day 5 of each menstrual cycle, take 2 tablets of 5mg once daily with meals for 5 days. On top of this, Zishen Yutai Pills placebo was added, starting from the 5th day
Sponsors
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: ? Meet the diagnostic criteria of polycystic ovary syndrome in Western medicine; ? Meet the TCM diagnostic criteria of spleen and kidney deficiency and phlegm-dampness obstruction syndrome; ? Women aged 20-40 years old with reproductive needs; ? Good mental condition, able to complete the questionnaire independently; ? Subjects and their families give informed consent, voluntarily sign the informed consent form, and voluntarily accept the treatment according to the requirements and cooperate with this study. ? The subjects and their families gave informed consent, voluntarily signed the informed consent form, and voluntarily accepted the treatment according to the requirements and cooperated with this study; (vi) No hormonal drugs or Chinese herbal medicines or proprietary Chinese medicines that tonify the kidney and spleen, resolve phlegm and dispel dampness have been used in the last 3 menstrual cycles.
Exclusion criteria
Exclusion criteria: ?Taking Chinese herbal medicines and proprietary Chinese medicines related to the treatment of polycystic ovary syndrome within 3 months prior to the trial, and those who have been treated with sex hormone drugs or contraceptive pills within 3 months; ? Combined gonadal hypoplasia, organic lesions of reproductive organs, thyroid disease, poorly controlled diabetes mellitus, hyperprolactinaemia, suspected Cushing's syndrome, congenital adrenal hyperplasia, gastrointestinal and digestive system diseases; ?Patients with combined heart, liver, kidney, gastrointestinal tract and other serious organic diseases; ?Patients with abnormal liver function (ALT, AST, ALP, GGT>2 times the upper limit of normal value), abnormal renal function (BUN>30mg/dl or serum creatinine>1.4mg/dl); ? Those who are allergic or hypersensitive to the drugs or food ingredients involved in this study; ? Those who have taken any antibiotics, probiotics, prebiotics, proton pump inhibitors within 30 days; (vii) Poor compliance, inability to return to the hospital in time to complete the visit, and difficulty in adhering to the completion of the entire clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Volume of follicles;Number of follicles;Thickness of the endometrium;ovulation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| TCM syndrome efficacy quantitative evaluation score;diversity, abundance of lingual flora;diversity, abundance of intestinal flora; | — |
Countries
China
Contacts
Public ContactLei Zeng
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed