Postoperative cognitive dysfunction
Conditions
Interventions
Test group:The patient received electroacupuncture pre stimulation for three consecutive days from 3 days before surgery to 1 day before surgery. Select the patients "Baihui point" and "Dazhui point",
Sponsors
The Second Affiliated Hospital of Nanjing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
65 Years to 89 Years
Inclusion criteria
Inclusion criteria: 1. Patients who meet the diagnostic criteria for femoral neck fractures. 2. Age range from 65 to 89 years old, regardless of gender. 3. ASA level II or III; 4. There is no cognitive impairment before surgery, MMSE score = 24 points, MoCA (Beijing version) score = 26 points (for those with less than 12 years of education, the total score will be added by 1 point as the final score); 5. Informed consent and voluntary participation in the trial. The process of obtaining informed consent should comply with GCP regulations.
Exclusion criteria
Exclusion criteria: 1. Preoperative cognitive impairment [MMSE score3 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE;MoCA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum S-100ß;Autophagy related proteins LC3-?;Inflammatory factor IL-1ß;Adverse reactions of electroacupuncture treatment;Complications of anesthesia surgery;Autophagy related proteins p62;Inflammatory factor IL-6;Inflammatory factor TNF-a; | — |
Countries
China
Contacts
Public ContactNiu Cong
The Second Affiliated Hospital of Nanjing University of Chinese Medicine
Outcome results
None listed