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Clinical study on the effect of bupivacaine liposome iliac fascia block prophylactic analgesia on perioperative cognitive function in elderly patients with hip fractures

Clinical study on the effect of bupivacaine liposome iliac fascia block prophylactic analgesia on perioperative cognitive function in elderly patients with hip fractures

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400081787
Enrollment
Unknown
Registered
2024-03-12
Start date
2024-04-01
Completion date
Unknown
Last updated
2024-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hip fractures in elderly patients

Interventions

Experimental group:Single dose bupivacaine liposome 266mg iliac fascia block
Control group:Single dose 0.375% ropivacaine 20-30ml iliac fascia block

Sponsors

Jiangsu University Affiliated Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 99 Years

Inclusion criteria

Inclusion criteria: ? Patients with hip fractures who are scheduled for elective surgery, including total hip replacement, semi hip replacement, PFNA (proximal femoral anti rotation intramedullary nail fixation), and the American Society of Anesthesiologists (ASA) grade II-III; ? Age = 65 years old, BMI 18-25; ? Agree to receive a preventive analgesic plan; ? Voluntary participation in research.

Exclusion criteria

Exclusion criteria: ? Preoperative visits revealed significant cognitive impairment with MMSE scores (see Appendix 2). Illiteracy<17 points, primary school<20 points, and middle school and above<24 points; ? History of hip surgery; ? History of opioid or alcohol abuse; ? History of chronic pain; ? Neurological disorders; ? Severe visual impairment; ? Anemia (Hb < 80g/L), coagulation disorders; ? Unable to communicate effectively with doctors verbally; ? Voluntary withdrawal from the study midway; ? Preoperative patients with basic diseases such as heart failure, seriously decreased respiratory function, severe arrhythmia, and poorly controlled hypertension and diabetes.

Design outcomes

Primary

MeasureTime frame
Pain;PCIA Press Times;Remedial analgesia frequency;

Secondary

MeasureTime frame
delirium;sleep quality;

Countries

China

Contacts

Public ContactJiang Peng

Jiangsu University Affiliated Hospital

doctorjp@163.com+86 139 1455 6527

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026