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Study on the correlation between dynamic changes of alpha-fetoprotein and prognosis in hepatocellular carcinoma patients undergoing liver resection

Study on the correlation between dynamic changes of alpha-fetoprotein and prognosis in hepatocellular carcinoma patients undergoing liver resection

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400081786
Enrollment
Unknown
Registered
2024-03-12
Start date
2023-09-01
Completion date
Unknown
Last updated
2024-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hepatocellular carcinoma

Interventions

b-AFP(+) group :Grouped according to AFP results, there were no interventions.
b-AFP(-) group:Grouped according to AFP results, there were no interventions.

Sponsors

The First Affiliated Hospital of Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) Research subjects: RHCC patients who sought medical treatment at the First Affiliated Hospital of Sun Yat-sen University from June 2006 to December 2019; (2) Primary and recurrent tumors with pathological diagnosis of HCC; (3) Hepatectomy was performed for both primary and recurrent tumors; (4) The patient has not received liver resection treatment, local therapy, or molecular targeted therapy in the past; (5) Liver, blood and kidney function are all good; (6) The age range is between 18 and 75.

Exclusion criteria

Exclusion criteria: (1) Thrombosis or distant metastasis of vascular or biliary tract tumors; (2) Incomplete clinical data; (3) loss of follow-up; (4) Liver, blood and renal insufficiency; (5) Other malignant tumors.

Design outcomes

Primary

MeasureTime frame
Alpha fetoprotein;

Secondary

MeasureTime frame
Age;Gender;Child Pugh class;Barcelona Clinic Liver Cancer staging;Etiology;Cirrhosis;Indocyanogen green 15-minute retention rate;Antiviral history;Tumor number and size;Portal vein thrombosis class;hepatitis B surface antigen(HbsAg);Hepatitis B virus-deoxyribonucleic acid;Diabetes;Neutrophil ratio;Lymphocyte ratio;Platelets(PLT);prothrombin time(PT);international normalized ratio(INR);Albumin ;serum total bilirubin(TBIL);alanine aminotransferase(ALT);aspartate aminotransferase(AST);gamma-glutamyltranspeptidase(?-GGT);Operation time;Blood loss;Blood transfusion;Operation method;Resection Margin;Tumor capsule;Complications;Tumor morphology;Microvascular invasion(MVI);

Countries

China

Contacts

Public ContactShunli Shen

The First Affiliated Hospital of Sun Yat-Sen University

shenshli@mail.sysu.edu.cn+86 136 3148 4663

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026