Sepsis
Conditions
Interventions
Experimental group:Prepare Chaiqin Chengqi decoction and take 80ml Q6h orally or gastric tube infusion. The temperature of the drug is maintained at 32-40 ?. Medication will be suspended at AGI level
Control group:Prepare a placebo and inject 80ml Q6h orally or through a gastric tube. The temperature of the drug is maintained at 32-40 ?. Medication will be suspended at AGI level 4. For patients wi
Sponsors
Suining Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Patients who meet the diagnostic criteria for sepsis, according to the 2016 3.0 sepsis diagnostic criteria (Singer et al., 2016), have a Sequential Organ Failure Assessment Score (SOFA) of = 2 points. (2) Simultaneously present with acute gastrointestinal injury (diagnosis and grading based on the guidelines developed by the ESICM Abdominal Issues Working Group). (3) Age 18 and above, regardless of gender. (4) Willing to participate in the experiment and sign an informed consent form.
Exclusion criteria
Exclusion criteria: (1) patients with malignancy. (2) Pregnant and lactating patients. (3) Gastrointestinal bleeding, mechanical intestinal obstruction, gastrointestinal necrosis, perforation. (4) Patients with varying degrees of mental disorders or mental illnesses. (5) Individuals with allergies to traditional Chinese medicine or other adverse reactions to traditional Chinese medicine.(6) Emergency surgical patients are required immediately upon admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AGI classification;intra-abdominal pressure;IAP;Sepsis score (SOFA);APACHE? score ;mortality;Start time of enteral nutrition; | — |
Secondary
| Measure | Time frame |
|---|---|
| Parenteral nutrition time;Antibiotic usage time;Anal exhaust time;Anal defecation time;Total hospitalization time;ICU stay time;white blood cell count;C-reactive protein;Procalcitonin;interleukin-6; | — |
Countries
China
Contacts
Public ContactXiaodi Li
Suining Central Hospital
Outcome results
None listed