Permanent pulp necrosis
Conditions
Interventions
Experiment group 1:Allogeneic SCAP implantation therapy
Experiment group 2:Allogeneic SHED implantation therapy
Control group:Conventional root canal treatment
Sponsors
The Third Affiliated Hospital of PLA Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: 1. Signing an informed consent form; 2. Age between 18 and 30 years old; 3. Anterior teeth or premolars with pulp necrosis due to caries, malformed central cusps, and wedge-shaped defects 4. (apical foramen diameter >=0.6mm), at least 1 tooth position (maximum 2 teeth position); 5. The researcher determines that the case is suitable for root canal treatment; 6. The researcher determines that the treated tooth can be preserved for at least 5 years; 7. The researcher determines that the affected tooth is eligible for stem cell implantation.
Exclusion criteria
Exclusion criteria: 1. The researcher determines that the study subject is unlikely to comply with the research procedures. 2. Uncontrollable pathological processes in the oral cavity. 3. Tooth occlusal trauma, bruxism, malocclusion. 4. The affected tooth accompanied by periapical cyst. 5. History of hereditary dental developmental disorders. 6. Cardiac diseases (Class II and above heart functional disorders). 7. Abnormal liver or kidney function (abnormal ALT, AST values; or creatinine, blood urea nitrogen values more than double the normal range). 8. Blood or immune system disorders. 9. Various infectious diseases. 10. Mental abnormalities or lack of behavioral autonomy. 11. Severe dental phobia. 12. Patients with hypersensitivity. 13. Women of childbearing age. 14. The researcher determines that systemic or local diseases may affect postoperative healing. 15. Planners and executors involved in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety evaluation of allogeneic stem cell transplantation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recurrent-caries; | — |
Countries
China
Contacts
Public ContactWei Wang
The Third Affiliated Hospital of PLA Air Force Medical University
Outcome results
None listed