Knee lesion
Conditions
Interventions
Experimental group:Timing of cluster analgesia management: patients with no pain/patients with mild pain were assessed at 2PM daily
Patients with moderate pain were assessed at 10AM and 2PM daily
Patients with persistent severe pain were evaluated once in q4 hours
The parameters of the analgesic pump were adjusted: (1) there was no PCA compression during the intervisit period, and the duration was reduced (duration =1.5ml: decreased by 10%, duration < 1.5ml: de
(2) When PCA was pressed more than 5 times between visits, the continuous volume was increased (the continuous volume =1.5ml was increased by 10%, the continuous volume < 1.5ml was increased by 0.1ml)
? The minimum duration is 0.1ml, and the maximum does not exceed the initial setting value
(4) PCA had compression but not more than 5 times between visits, which remained unchanged.
Control group:The patients' pain was assessed by QoR-15 scale and various items of analgesia evaluation system at 2PM every day.Patients with moderate to severe pain and adverse reactions were notifie
Sponsors
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Patients undergoing knee replacement surgery under tracheal intubation and general anesthesia at selected time 2) ASA I-II level 3) Age 65-75 4) BMI18~28 5) Preoperative MMSE score: primary school literate =20 points, secondary school literate =22 points, university literate =24 points 6) For patients with intravenous patient-controlled analgesia after surgery, the postoperative analgesia follow-up data were recorded completely 7) Voluntarily participate in the research subject and sign the informed consent
Exclusion criteria
Exclusion criteria: 1) Study participants who took strong opioids or monoamine oxidase inhibitors (MAOIs) before 2 weeks 2) Laboratory test values meet the following criteria and are determined by the investigator to be unsuitable for participants: Liver and kidney function: ALT and/or AST > 1.5 times the upper limit of normal, or BUN/Urea > 1.5 times the upper limit of normal, or Cr > the upper limit of normal, or dialysis treatment within 28 days prior to surgery: • Blood pressure: sitting SBP > 160mmHg or SBP < 90mmHg; • Oxygen saturation (unoxygenated) < 94% : 3) Concurrent critical illness, including severe liver dysfunction (e.g., liver failure), chronic kidney failure (e.g., glomerular filtration rate < 30ml/min) 4) Patients with acute or severe bronchial asthma or hypercapnia, severe chronic obstructive pulmonary disease or pulmonary heart disease, with significant respiratory depression or high risk of respiratory depression 5) History of drug abuse and drug use within the previous 2 years 6) A history of alcohol abuse within the previous 3 months, defined as regular drinking of more than 14 times/week (1 ˜150ml wine or 360ml beer or 45ml spirits) 7) Those who have neuromuscular defects caused by various reasons and can not carry out joint function rehabilitation exercise after surgery 8) Patients with more than severe intraoperative knee deformity (internal and external inversion, straightening, flexion deformity)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 Recovery Quality Scale;Length of stay; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale;Nausea and vomiting;Stun;satisfaction; | — |
Countries
China
Contacts
Public ContactLi Ruolan
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed