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Effects of single-site and double-site intermittent theta burst stimulation on post-stroke cognitive impairment: A randomized controlled trial

Effects of single target and double target intermittent theta burst stimulation on post-stroke cognitive impairment: A randomized controlled trial

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400081741
Enrollment
Unknown
Registered
2024-03-11
Start date
2023-09-08
Completion date
Unknown
Last updated
2024-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

the experimental group:double-site intermittent theta burst stimulation
the control group:signal-site intermittent theta burst stimulation

Sponsors

Zhejiang Rehabilitation Medical Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1: Conform to the diagnostic criteria of stroke 2: First onset, 1-6 months after the occurrence of stroke events 3: There was mild to moderate cognitive impairment, and the simple mental state examination scale score was 10-26 points.; 4: Right handed 5: No serious aphasia, especially fluent aphasia, can cooperate to complete cognitive assessment 6: The vital signs were stable, and no neurological symptoms progressed 7: Normal cognitive function before stroke 8: The patient or his legal guardian agreed to participate in the trial and signed the informed consent

Exclusion criteria

Exclusion criteria: 1: CT or MRI confirmed that the left prefrontal cortex was completely damaged 2: Skull defect 3: There are metal foreign bodies near the stimulation coil or the stimulated scalp, such as intracranial metal implants, cochlear implants, and built-in pulse generators ( brain pacemakers, cardiac pacemakers ) 4: History of brain tumors, history of brain trauma, history of seizures and risk of seizures 5: Cognitive impairment caused by Alzheimer 's disease, Parkinson 's disease and other diseases 6: Any mental comorbidities and emotional disorders that may affect the test results.

Design outcomes

Primary

MeasureTime frame
Functional Near Infrared Spectroscopy;quantitative Electroencephalography;

Secondary

MeasureTime frame
Loewenstein Occupational Therapy Cognitive Assessment;

Countries

China

Contacts

Public ContactJianer Chen

Zhejiang Rehabilitation Medical Center, Hangzhou, Zhejiang, China

chenje@zcmu.edu.cn+86 189 5807 3235

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026