sleep disorder
Conditions
Interventions
Intervention group:combined physical and intellectual rehabilitation training
Control:None
Sponsors
The Second Affiliated Hospital of South China University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for observational cohort 1) 45 = age = 59 years old; 2) Clearly diagnose sleep disorders according to the International Classification of Sleep Disorders (ICSD-3); 3) Ability to cooperate in completing neuropsychological assessments; 4) Be able to understand the purpose and procedures of this study and sign a written informed consent form. Inclusion criteria for intervention cohorts If the criteria for inclusion in the observational cohort are met, it is still necessary to meet the following requirements: 1) According to the International Classification of Sleep Disorders (ICSD-3), the type of sleep disorder is defined as insomnia; 2) A history of chronic insomnia for at least 3 months, with sleep duration 5 points or in line with the "2018 China Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Disorders (5): Diagnostic criteria for MCI in "Diagnosis and Treatment of Mild Cognitive Disorders"; 5) Not accompanied by other types of sleep disorders: such as respiratory related sleep disorders, sleep awake circadian rhythm disorders, etc.
Exclusion criteria
Exclusion criteria: 1) Serious systemic medical diseases of cardiovascular, endocrine, renal, or liver systems; 2) The state of acute exacerbation or attack of a chronic disease; 3) Acute infectious diseases; 4) Diseases related to potential cognitive impairment, including focal brain damage, traumatic brain injury with loss of consciousness or mental disorder, as well as cognitive impairment caused by nervous system diseases related to neurosyphilis, HIV central nervous system infection, Parkinson's disease, or Lewy body disease, and cognitive impairment caused by systemic diseases such as B-vitamin deficiency and hypothyroidism; 5) Mental disorders, including depression (Hamilton Depression Scale HAMD>35), anxiety (Hamilton Anxiety Scale HAMA>29), alcohol or drug abuse; 6) Neuroradiologic evaluation of conventional MR imaging revealed more than one lacunar lesion, or patchy, diffuse leukoaraiosis; 7) Clearly diagnose patients with malignant tumors; 8) Incomplete information or refusal to participate in the investigation or inability to cooperate with the test; 9) Patients who are participating in other clinical trials but have not reached the main study endpoint.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of cognitive impairment;The incidence of dementia;Assessment of daily life activity ability;parameters of polysomnography; | — |
Secondary
| Measure | Time frame |
|---|---|
| The occurrence of stroke;Sleep quality indicators;Health economics indicators;Laboratory inspection indicators; | — |
Countries
China
Contacts
Public ContactMei Yuan
The Second Affiliated Hospital of South China University
Outcome results
None listed