Severe anthrax
Conditions
Interventions
Divide patients into death group and survival group based on their clinical outcomes at 28 and 90 days:None
Sponsors
Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age =18 years old, gender unlimited. 2. Meet the following diagnostic criteria for severe anthrax: (1) Smear examination and culture of various secretions, excreta, blood, cerebrospinal fluid, etc., to find typical and capsulated large bacillus, which can be further diagnosed by fluorescent antibody staining, beaded wet sheet examination, specific phage test, animal inoculation, etc. (2) Multiple organ function impairment (MODS) of brain, heart, liver, kidney, blood clotting or more than one organ failure of brain, heart, liver, kidney, blood clotting.
Exclusion criteria
Exclusion criteria: Patients identified by the investigators as having conditions that affect short-term survival and are not eligible for inclusion in the program.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28 - and 90-day mortality for severe anthrax; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of respiratory, circulatory, nervous, digestive and coagulation complications in severe anthrax;Peripheral blood biomarkers associated with death at 28 days and 90 days from severe anthrax;Clinical treatment of severe anthrax improves mortality at 28 and 90 days; | — |
Countries
China
Contacts
Public ContactQin Ning
Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology
Outcome results
None listed