Cardiac disease
Conditions
Interventions
Ciprofol group:Intravenous bolus injection of 5ug/kg of alfentanil, followed by slow injection (30 seconds) of 0.5mg/kg of Cipofol for anesthetic sedation during transesophageal echocardiography.
Proprofol group:Intravenous bolus injection of 5ug/kg of alfentanil, followed by slow injection (30 seconds) of 2mg/kg of Propofol for anesthetic sedation during transesophageal echocardiography.
Sponsors
Xiamen Cardiovascular Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Ages 18-90 years (2) Have indications for painless transesophageal echocardiography (3) Patients with good cognitive status (4) Body mass index (BMI) of 18-30kg/m2 (5) Normal liver and kidney function
Exclusion criteria
Exclusion criteria: (1) Emergent surgery (2) ASA class V patients (3) Patients with clinically diagnosed coagulation disorders, severe liver or kidney impairment(4) History of upper gastrointestinal bleeding within the past three months(5) Abnormalities in the esophagus or stomach, or history of related surgeries (6) History of psychiatric disorders or long-term use of analgesic drugs (7) Left ventricular ejection fraction (EF) <25% (8) Inability to cooperate with the study for any reason, such as language comprehension, mental illness, inability to travel to the study center, etc. (9) Use of other investigational drugs or participation in other clinical trials within the 3 months prior to enrollment(10) The investigator deems that inclusion in this trial is not appropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adverse events related to sedation;Cough reflex; | — |
Secondary
| Measure | Time frame |
|---|---|
| Body's movements;Pain upon intravenous injection; | — |
Countries
China
Contacts
Public ContactGuoshengwen, Yanpianpian, Jianglulu
Xiamen Cardiovascular Hospital
Outcome results
None listed