median effective does
Conditions
Interventions
Youth group ( aged 18 ~ 40 years old ):Spinal anesthesia was followed by sedation with ciprofol
Middle-aged group ( aged 41-64 years ):Spinal anesthesia was followed by sedation with ciprofol
The elderly group ( aged 65-80 years ):Spinal anesthesia was followed by sedation with ciprofol
Sponsors
Department of Anesthesiology, Affiliated Hospital of
Jiangsu University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Elective surgery, planned to lower extremity orthopedic surgery under subarachnoid block ; 2.Men and women are not limited ; 3.Age 18-80 years old ; 4.ASA grade I ~ II ; 5.BMI 18 ~ 26 kg / m2 ; 6. Fully understand the research content.
Exclusion criteria
Exclusion criteria: 1.Severe liver and kidney dysfunction ; 2.Severe respiratory diseases or difficult airway ; 3.Severe cardiovascular and cerebrovascular diseases ; 4.Allergic to ciprofol ; 5. Difficult airway ; 6.Psychiatric nervous system diseases or long-term use of sedative and analgesic drugs, or a history of sedative and analgesic drugs within 1 week ; 7.There are contraindications of spinal anesthesia such as abnormal coagulation function or preoperative use of anticoagulant drugs ; 8.Patients refused.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dosage of ciprofol during sedation;Whether the degree of sedation is satisfactory;The 50% effective dose ( ED50 ) ,50% confidence interval, 95 % effective dose ( ED95 ) and 95 % confidence interval when satisfactory sedation were obtained.; | — |
Secondary
| Measure | Time frame |
|---|---|
| MOAA/ S scores;bispectral index;blood pressure;heart rate;blood oxygen saturation; | — |
Countries
China
Contacts
Public ContactHuang Hui
Department of Anesthesiology, Affiliated Hospital of Jiangsu University
Outcome results
None listed