Mental Illness
Conditions
Interventions
positive memory intervention group:positive memory retrieval
neutral memory intervention group:neutral memory retrieval
Sponsors
Peking University Sixth Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Healthy subjects: Han Chinese, aged 18-60, gender non-specific; education level of high school or above; voluntary participation in the study and signing of the informed consent form. Post-traumatic stress disorder subjects: Han Chinese, aged 18-60, gender non-specific; meeting the diagnostic criteria as per the "Guidelines for the Prevention and Treatment of Post-Traumatic Stress Disorder (2019)"; education level of high school or above; voluntary participation in the study and signing of the informed consent form.
Exclusion criteria
Exclusion criteria: (1) According to ICD-10 and the MINI-International Neuropsychiatric Interview, individuals are diagnosed with major mental disorders based on DSM-5 criteria, including schizophrenia spectrum and other psychotic disorders, bipolar disorders, depression and anxiety disorders, obsessive-compulsive disorder, dementia, and neurocognitive disorders. (2) Those with a history of substance abuse, such as nicotine and drugs; patients who meet the DSM-5 criteria for substance-related and addictive disorders according to ICD-10 and MINI, including psychiatric disorders caused by substance abuse. (3) Individuals with severe somatic diseases, such as diagnosed diabetes, hypertension, thyroid disease, heart disease, malignant tumors, etc. (4) Patients who previously used psychotropic drugs, such as antidepressants, mania drugs, or other medications for the treatment of psychiatric diseases, and have not completed drug washout at the start of the experiment. (5) Those currently taking any medications, including antipyretics, analgesics, sedative-hypnotics, antibiotics, traditional Chinese medicine for conditioning, and topical medications, etc. (6) Presence of medical factors causing chronic physical discomfort (such as chronic pain, itching, etc.). (7) Individuals with a tendency to bleed or anemia. (8) Individuals with contraindications for MRI scanning, or those with brain structure abnormalities found in MRI examinations. (9) Participants with poor compliance who cannot independently cooperate with the experiment. In this project, all experiments recruited participants using uniform inclusion and exclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Polysomnography;fMRI date; | — |
Secondary
| Measure | Time frame |
|---|---|
| Concentrations of glucocorticoids and high-sensitivity C-reactive protein in the bloodstream; | — |
Countries
China
Contacts
Public ContactYu Zhoulong
Peking University Sixth Hospital
Outcome results
None listed