postoperative delirium
Conditions
Interventions
Esketamine group:Esketamine was continuously infused with 0.3 mg/kg/h intraoperatively
Control group:Normal saline was infused at the same rate intraoperatively
Sponsors
Chengdu integrated TCM &Western Medicine Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1)Patients undergoing elective hip fracture surgery(including femoral neck, femoral head, intertrochanteric, or subtrochanteric fracture), (2) age = 65 years old, (3) a body mass index of 18 to 30 kg/m^2, (4) an American Society of Anesthesiologists grade I-III, and(5) Informed consent for anesthesia was signed voluntarily.
Exclusion criteria
Exclusion criteria: Multiple injuries, multiple fractures and fracture types other than the inclusion criteria (pathological, pelvic and femoral fractures);Combined neurological diseases (such as parkinsonism) or psychiatric diseases (such as schizophrenia) or preoperative mini-mental State Examination (MMSE) score < 23;Unable to complete the neuropsychological assessment and score determination for any reason (severe visual, auditory, or language communication impairment); intolerance or allergy to esketamine; history of liver and kidney dysfunction; a history of alcohol, psychotropic drugs abuse; severe intraoperative or postoperative complications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of delirium within the first 3 postoperative days; | — |
Secondary
| Measure | Time frame |
|---|---|
| subtypes of delirium;duration of delirium;30-day all-cause mortality;pain score within the first 3 days after surgery;length of hospitalization; | — |
Countries
China
Contacts
Public ContactShao Changhui
Chengdu integrated TCM &Western Medicine Hospital
Outcome results
None listed