Obesity/Overweight
Conditions
Interventions
Vitamin D group:Dietary counseling combined vitamin D supplementation (5000 IU for first dose then 1200 IU/d)
Control group:Dietary counseling combined placebo supplementation
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. 18~60 years old; 2. Deficiency or insufficiency of VD (serum 25(OH)D =24 kg/m^2, and weight change < 5 kg in the past 12 months.
Exclusion criteria
Exclusion criteria: 1. Those who regular use of any drugs and supplements containing vitamin D and/or its active forms within 6 months prior to study initiation; 2. With vitamin D hypersensitivity; 3. Being peri-menstruating or postmenopausal; 4. With hyper-phosphorus, hypercalcemia and hypercholesterolemia; 5. With diabetes mellitus or severe cardiovascular and cerebrovascular diseases; 6. With acute inflammation; with digestive diseases; 7. With cardiac or renal insufficiency; 8. Currently in pregnancy, lactation and perimenopause; 9. With severe smoking (> 5 cigarettes per day) or drinking (men > 4 and women > 2 standard drinks/week) were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body composition (body fat percentage); | — |
Secondary
| Measure | Time frame |
|---|---|
| 25(OH)D;Glycolipid metabolism parameters (fasting glucose, fasting insulin, HOMA-ß, HOMA-IR, QUICKI, triglyceride, total cholesterol, HDL-c, LDL-c etc.);Adipocytokines (leptin, adiponectin and visfatin etc.);Body composition (fat mass, fat mass index , visceral fat area, appendicular muscle mass and appendicular muscle mass index etc.);Anthropometric measurements (body weight, BMI, waist circumference, waist-to-hip ratio, calf circumference , grip strength and Chinese visceral adiposity index etc.);Liver FibroScan indices (controlled attenuation parameter and liver stiffness value); | — |
Countries
China
Contacts
Public ContactQian Ren
Department of Clinical Nutrition, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed