Acute ischemic stroke
Conditions
Interventions
Intra-arterial urokinase thrombolysis plus standard treatment group:Intra-arterial urokinase thrombolysis plus standard treatment
Sponsors
The Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1)Age = 18 years old; 2)Within 24 hours of stroke onset; 3)Without visible large or medium vessel occlusion on DSA/CTA/MRA examination. 4)National Institutes of Health Stroke Scale (NIHSS) score = 6 points; 5)Written informed consent signed by the patient or family members.
Exclusion criteria
Exclusion criteria: 1)Confirmed intracranial hemorrhage by computed tomography (CT) or magnetic resonance imaging (MRI); 2)Pre-stroke mRS score = 2; 3)Digital subtraction angiography suggests vascular rupture, dissection, extravasation of contrast agent or other complication; 4)Alberta Stroke Program Early CT Score (ASPECTS) 1.7; 9)Blood glucose 22.2mmol/L (400mg/dl), platelets 220µmol/L(2.5mg/dl)); 12)Intracranial aneurysm, or arteriovenous malformation; 13)Brain tumor(s) with mass effect; 14)Any disease that leads to an expected lifespan of less than 6 months; 15)Unable to complete follow-up as expected; 16)Large- or medium-sized vessel occlusion found on DSA/CTA/MRA examination; 17)Currently participating in other clinical trial; 18)Patients received Intravenous Thrombolysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale score 0-1;Symptomatic intracranial hemorrhage;Death; | — |
Secondary
| Measure | Time frame |
|---|---|
| Global outcome analysis;Modified Rankin Scale score of 0-2;EQ-5D scale score;any intracranial hemorrhage;NIHSS score at 5 to 7 days; | — |
Countries
China
Contacts
Public ContactWenjie Zi
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed