Diabetic foot ulcer
Conditions
Interventions
Test group 1:rhGM-CSF was administered locally to diabetic foot ulcer wounds every three days (2.0µg/c?)
Test group 2:rhGM-CSF was administered locally to diabetic foot ulcer wounds every three days (4.0µg/c?)
Test group 3:rhGM-CSF was administered locally to diabetic foot ulcer wounds every six days (2.0µg/c?)
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) T2DM patients, who met WHO1999 diagnostic criteria; (2) Wagner I-II level is adopted for DFU classification; (3) over 18 years of age; (4) The first-line conventional treatment of diabetic wounds did not heal for 3 weeks.
Exclusion criteria
Exclusion criteria: 1) DKA and hyperosmolar patients; (2) Patients with lower extremity great artery occlusion or ABI< 0.60; (3) PEDIS infection of the foot was classified into grades 3-4; (4) Patients with severe coronary heart disease, cerebral infarction, heart failure, renal failure; (5) Patients with malignant tumors; (6) Patients using immunosuppressants; (7) Pregnant and lactating women.(8) Patients who are participating in other clinical trials; (9) Researchers consider other reasons not appropriate for clinical trial participants.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| HE staining;Capillary density analysis;VEGF-A levels;M1/M2 macrophage level; | — |
Primary
| Measure | Time frame |
|---|---|
| Wound area; | — |
Countries
China
Contacts
Public ContactShao Shiying
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed