Osteoporosis,spine
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria: - menopause time = 1 year; - -1 > DXA T score > -2.5 SD; - body mass index (BMI) < 30 kg/?.
Exclusion criteria
Exclusion criteria: Exclusion criteria: - Engaging in high-impact training (with ground reaction forces greater than jogging) more than once a week, or resistance exercise exceeding 45 minutes per week within the past two years; - Use of medications that affect bone metabolism or density (such as prolonged corticosteroid, thyroxine, or thiazide use); - Secondary OP or osteoporotic fractures; - Any contraindications for strenuous physical activity (such as uncontrolled cardiovascular disease, malignancy, or hypertension).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in lumbar spine bone mineral density; 6 months (before and after intervention); Bone mineral density is an indicator of evaluating the strength of human bones, with lower bone mineral density a marker of osteoporosis;Changes in lumbar spine maximum compression force; 6 months (before and after intervention); Maximum compression force is an indicator of evaluating the strength of human bones, with lower maximum compression force a marker of osteoporosis;Joint reaction force (BW); 6 months (post intervention) ;Paravertebral muscle force ; 6 months (post intervention) ;Correlation coefficient between changes in bone mineral density and joint reaction force;Correlation coefficient between changes in bone mineral density and mechanical stimulation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in Young's Modulus (GPa); 6 months (pre and post intervention) ;Change in Strain; 6 months (pre and post intervention); This analyses the change in length of the bone over the time period, expressed as % change. ;Change in Stiffness (N/mm); 6 months (pre and post intervention) ;Change in height; 6 months (pre and post intervention) ;Change in weight; 6 months (pre and post intervention) ;Change in BMI; 6 months (pre and post intervention) ;Changes in lumbar spine bone mineral density of the integral bone (mg HA/cm3); 6 months (pre and post intervention); Volumetric Bone mineral density ;Changes in lumbar spine bone mineral density of trabecular bone (mg HA/cm3);6 months (pre and post intervention); Volumetric Bone mineral density ;Changes in lumbar spine bone mineral density of cortical bone (mg HA/cm3); 6 months (pre and post intervention); Volumetric Bone mineral density ;Change in lumbar spine bone mineral density (g/c?); 6 months (pre intervention) ;Change in Strength (N); 6 months (pre and post intervention) ;Lumbar spine DAX CT QCT image;Kinematic and dynamic data;Electromyographic signal; | — |
Countries
China
Contacts
Tianjin University