Septic shock
Conditions
Interventions
Control group:Normal saline plus standard treatment
Sponsors
Taizhou Hospital of Zhejiang Province
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 years and over; 2. Diagnosed as septic shock based on of Sepsis-3 definition from the international consensus published in 2021. This definition includes suspected or confirmed infections, an increase in Sequential Organ Failure Assessment (SOFA) score by 2 or more points, the need for vasopressor therapy due to hypotension, and a lactate level greater than 2 mmol/L; 3.Tracheal intubation
Exclusion criteria
Exclusion criteria: 1. Pregnancy; 2. Allergic to methylene blue; 3.Recent intake (4 weeks) of a selective serotonin reuptake inhibitor; 4. With glucose-6-phosphate-dehydrogenase deficiency; 5.Factors that seriously interfere with sublingual microcirculation imaging (maxillofacial surgery or mucosal bleeding injury, etc.); 6.Other Types OF SHOCK
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Microvascular flow index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intensity of vasoactive drug use;28-day mortality rate;Liver function;renal function;Coagulation function;Sequential Organ Failure Assessment Scores;AcutePhysiology and Chronic Health Evaluation Scores;Lactic acid; | — |
Countries
China
Contacts
Public ContactYinghe Xu
Taizhou Hospital of Zhejiang Province
Outcome results
None listed