Cognitive Impairment
Conditions
Interventions
Group without cognitive impairment:N/A
Sponsors
The People's Hospital of Bao'an, Shenzhen
Eligibility
Sex/Gender
Female
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1 Perimenopausal women without cognitive impairment: (1) Meet diagnostic criteria for perimenopause; (2) Are between 40-60 years of age; (4) Satisfy an SCD-Q9 score of <5; (5) Satisfy a MoCA score of =26; (if =12 years of education, add 1 point to the score) (6) Right sharp hand; (7) Signed informed consent and voluntary participation. 2 .SCD perimenopausal women: (1) Meet the diagnostic criteria for SCD; (2) Meet perimenopausal diagnostic criteria; (3) Aged between 40-60 years old; (4) Satisfy SCD-Q9 score =5; (5) Satisfaction of a MoCA score of =26; (if =12 years of education, add 1 point to the score) (6) Right sharp hand; (7) Signed informed consent and voluntary participation. 3. MCI perimenopausal women: (1) Meet MCI diagnostic criteria (2) Meet perimenopausal diagnostic criteria: (3) Are between 40-60 years of age; (4) Satisfy a MoCA score of between 18-25; (if =12 years of education, add 1 point to the score) (5) Right sharp hand; (6) Signed informed consent to participate voluntarily.
Exclusion criteria
Exclusion criteria: (1) A history of mental illness; (2) A history of neurological disorders; (3) History of alcohol or drug abuse; (4) Surgical menopause (history of hysterectomy and bilateral adnexa removal); (5) Tumors of the reproductive system and vaginal bleeding of unknown etiology; (6) Hormonal drugs in the last 3 months prior to participation in the study; (7) Those who are unable to complete the assessment of indicators, such as severe aphasia, deafblindness, illiteracy, etc; (8) Participating in other research trials that affect the results of this study; (9) Not signing the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective Cognitive Decline Questionnaire9 (SCD-Q9);Montreal Cognitive Assessment Scale (MoCA Scale);N-back mission; | — |
Secondary
| Measure | Time frame |
|---|---|
| ApoE gene polymorphism detection;Menopause Rating Scale (MRS);Self-rating Scale for Anxiety (SDS);Depression Screening Scale (PHQ);Pittsburgh Sleep Quality Index (PSQI); | — |
Countries
China
Contacts
Public ContactChen Shangjie
The People's Hospital of Bao'an, Shenzhen
Outcome results
None listed