Chronic moderate to severe insomnia
Conditions
Interventions
Dexmedetomidine treatment group:Dexmedetomidine infusion starts at 22:00 each night, with a slow pump infusion at a dose of 0.5µg/kg over a duration of 15 minutes. Subsequently, the infusion is mainta
Conventional treatment group:The same routine CBTI treatment as dexmedetomidine treatment group was carried out to find the cause of insomnia, and sleep hygiene education was carried out to correct th
Patients were treated with benzodiazepine agonists or hypnotic agents such as nonbenzodiazepines or melatonin agonists.
Sponsors
The Second Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria of ICSD-3 chronic insomnia; (2) 18-65 years old; (3) ISI score =15; (4) People who have taken two or more drugs to improve sleep in the past, but are still not satisfied with the current treatment; (5) Good compliance, willing to accept this therapy.
Exclusion criteria
Exclusion criteria: (1) Pregnant or lactating women; (2) Chronic insomnia that can be explained by the primary disease; (3) Medical history or psychiatric disorders that the investigator considers to affect the safety of the subjects or interfere with the study evaluation; (4) Abnormal electrocardiogram; (5) Planned or unplanned suicidal thoughts at the time of screening or within 6 months after screening; Or have attempted suicide in the past 10 years; (6) Clinically significant diseases (e.g., cardiovascular diseases; Respiratory diseases; Digestive system diseases; Liver function damage; Kidney disease; Nervous system diseases; Endocrine system diseases; Infectious diseases; Mental illness; History of malignancy) or chronic pain that the investigators felt might affect the safety of the subjects or interfere with the study's assessment. Subjects whose sedatives were contraindicated for safety reasons due to their occupation or activity were also excluded. (7) Currently diagnosed sleep-related breathing disorders included obstructive apnea, periodic limb movement disorder, restless legs syndrome, circadian rhythm disorder or narcolepsy; (8) Patients were lost to follow-up due to various reasons, patients withdrew from the follow-up due to other random reasons; (9) Patients with a history of alcoholism or excessive consumption of coffee or strong tea.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Insomnia severity index;Hamilton Anxiety Scale;Hamilton Depression Scale; | — |
Countries
China
Contacts
Public ContactXude Sun
The Second Affiliated Hospital of Air Force Medical University
Outcome results
None listed