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The effects of different doses of dexmedetomidine combined with dexamethasone and ropivacaine on analgesic effect and recovery quality of transversus abdominis plane block in patients undergoing cesarean section : a double-blind controlled trial

The effects of different doses of dexmedetomidine combined with dexamethasone and ropivacaine on analgesic effect and recovery quality of transversus abdominis plane block in patients undergoing cesarean section : a double-blind controlled trial - The effects of different doses of dexmedetomidine combined with dexamethasone and ropivacaine on analgesic effect and recovery quality of transversus abdominis plane block in patients undergoing cesarean section : a double-blind controlled trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400081531
Enrollment
Unknown
Registered
2024-03-04
Start date
2024-03-05
Completion date
Unknown
Last updated
2024-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The postoperative analgesia and quality of recovery in patients undergoing cesarean section

Interventions

Group C: 8mg dexamethasone +0.375% ropivacaine:Bilateral transversus abdominis plane block was performed under ultrasound guidance after operation. Group C was given 8mg dexamethasone +0.375% ropivaca
D1:0.5ug/kg dexmedetomidine +8mg dexamethasone +0.375% ropivacaine:Bilateral transversus abdominis plane block was performed under ultrasound guidance after operation. Group D1 was given dexmedetomid
D2: 1ug/kg dexmedetomidine +8mg dexamethasone +0.375% ropivacaine:Bilateral transversus abdominis plane block was performed under ultrasound guidance after operation. Group D2 was given dexmedetomidi

Sponsors

Department of Anesthesiology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, China
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 42 Years

Inclusion criteria

Inclusion criteria: aged 20-42 years, body mass index of 21-30 kg/m2, American Society of Anesthesiologists Physical Status I-III gestational weeks at 37-42 week

Exclusion criteria

Exclusion criteria: Platelet count < 70×109 /L, significantly abnormal coagulation function, severe spinal deformity and other spinal anesthesia contraindications, unable to understand VAS pain score or unable to cooperate with the test, known allergy to study drugs or other study drugs, known TAPB puncture site infection, preoperative use of sedative, hypnotic, analgesic drugs, history of neurological and psychiatric diseases, and other complications. Severe heart, lung, liver and kidney dysfunction.

Design outcomes

Primary

MeasureTime frame
VAS pain scores at rest and during movement at 6h, 12h, 24 h, and 48h after surgery;

Secondary

MeasureTime frame
Duration of postoperative sensory block;The time to gastrointestinal recovery,;The frequency of postoperative nausea and vomiting and the use of antiemetic drugs;The QoR-15 scale was used to evaluate the quality of recovery at 1, 3, and 7 days after surgery;

Countries

China

Contacts

Public ContactGu Yang

Department of Anesthesiology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, China

499023233@qq.com+86 151 2197 9699

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026