Complex esophageal stricture
Conditions
Interventions
Experimental group:Sequential treatment with endoscopic incision combine with local triamcinolone acetonide injection
Control group:Sequential treatment with endoscopic dilation combine with local triamcinolone acetonide injection
Sponsors
Air Force Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Meet the limited CES inclusion criteria of this project (esophageal stenosis with a long segment between 2 and 5cm, after traditional dilatation3) Recurrent esophageal sricture at second or more times); (2) Willing to receive sequential therapy with EBD or EI combined with triamcinolone; (3) Patients whose general condition can tolerate general anesthesia and endoscopic treatment; (4) Patients can nor eat semi-liquid and solid food (Stooler score =3); (5) Those who are willing to participate in the clinical trial and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Malignant esophageal stricture or external pressure stricture; (2) Esophageal stricture with esophageal fistula or acute active inflammation (including infectious and non-infectious esophagitis); (3) Patients with triamcinolone hypersensitivity; (4) Severe abnormal coagulation function, cardiopulmonary diseases, etc., can not tolerate endoscopic treatment under general anesthesia; (5) Patients with severe diseases of other organs with an expected survival time of less than 6 months; (6) Patients with poor compliance and unable to follow the study design for sequential treatment; (7) Other situations that cannot cooperate with the completion of clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of dysphagia-free; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of treatments;Treatment interval;Medium and long term efficacy;The rate of significant efficacy;Restricture rate;Quality of life;Nutritional status;Length of stay; | — |
Countries
China
Contacts
Public ContactShoubin Ning
Air Force Medical Center
Outcome results
None listed