Burn scar
Conditions
Interventions
Test area:Timolol maleate eye drops wet compress once a day (21 days in total)
Control area:Physiological saline wet compress once a day (21 days in total)
Sponsors
Department of Burns and Cutaneous Surgery, XijingHospital, First Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-60 years old, regardless of gender; 2. The healing area of deep partial thickness burn was = 5% of the total body surface area (TBSA); The diagnosis and judgment are completed by two attending physicians or above; 3. Within one week after burn wound healing; 4. There is no infectious wound around the healing site; 5. Subjects or immediate family members are fully informed and voluntarily sign the informed consent form, and can complete the trial and follow-up according to the requirements of the protocol.
Exclusion criteria
Exclusion criteria: 1. Allergic to the study drug (i.e. Timolol Maleate Eye Drops); 2. Bronchial asthma or history of bronchial asthma, severe chronic obstructive pulmonary disease; 3. Sinus bradycardia, II or III degree atrioventricular block, obvious heart failure, cardiogenic shock; 4. Patients with definite severe dysfunction of heart, brain, liver, kidney and other organs; 5. Patients with psoriasis, diabetes, immunodeficiency disease, chronic skin or connective tissue disease, coronary artery disease, hyperthyroidism, myasthenia gravis, spontaneous hypoglycemia or history of drug abuse; 6. Users of insulin, oral hypoglycemic drugs, non-steroidal anti-inflammatory drugs, corticosteroids, and any drugs that affect the evaluation of study results; 8. Patients with scar constitution; 9. Those enrolled in other clinical trials within 3 months before screening; 10. Pregnant or lactating women; 11. Thoes who are not suitable to participate in the research according to the judgment of the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vancouver scar scale;Blood perfusion measured by laser Doppler flowmetry; | — |
Secondary
| Measure | Time frame |
|---|---|
| Scar thickness measured by ultrasound; | — |
Countries
China
Contacts
Public ContactJun Li
First Affiliated Hospital of Air Force Medical University
Outcome results
None listed