Nonarteriotic anterior ischemic optic neuropathy
Conditions
Interventions
Intra-arterial treatment:Ophthalmic-artery superselective therapy
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Patients clinically diagnosed with unilateral non-arterial ischemic optic neuropathy within 1 month (2) Age between 40 and 70 (3) BCVA=0.1 (4) Voluntarily participate in the clinical trial and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients diagnosed with bilateral NAION. (2) Patients with features of arterial ischemic optic neuropathy: CRP>10mg/L, Erythrocyte sedimentation rate > ULN ( Male 15mm/h, Female 20mm/h) (3) Coagulation function: International Normalized ratio (INR) > 1.4, and activated partial thromboplastin time (APTT) > 34s. (4) Blood routine examination: Absolute value of peripheral blood neutrophils (ANC) 1.5 x ULN (normal upper limit 17.1µmol/L); Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) > 5 x ULN (normal upper limit 40U/L); Albumin < 20 g/L. (6) Renal function: serum creatinine (Scr) was greater than the maximum reference concentration (Male 1.7 mg/dL, Female 1.4 mg/dL). (7) Any conditions that the researchers consider necessary to exclude from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual field index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Best-corrected visual acuity;Improvement rate of papilledema;Improvement rate of macular retinal edema;Retinal nerve fibre layer thickness (RNFL); | — |
Countries
China
Contacts
Public ContactXuyang Wen
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed