esophageal cancer
Conditions
Interventions
control group:The control group received an equivalent volume of 0.9% saline for the same duration.
esketamine group:After induction, the esketamine group received a continuous infusion at 0.02 mgkg-1hr-1 until the end of surgery, and PCIA (1 mg/kg esketamine+sufentanil 1.5) µg/kg).
Sponsors
The Fourth Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Age = 18 years old, regardless of gender; (2) Patients planning to undergo elective radical surgery for esophageal cancer; (3) ASA score levels I-III; (4) Voluntarily sign an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Expected hospitalization time<48 hours; (2) Individuals who are known to be allergic to the active ingredients or excipients of ketamine hydrochloride injection; (3) Severe consciousness disorders or the presence of mental system diseases; (4) Have a serious history of cardiovascular disease (presence of congestive heart failure, severe angina attacks, or unstable angina or myocardial infarction within 6 months); (5) Pregnant or lactating patients; (6) Patients who have received immunosuppressive therapy (such as PD-1 inhibitors), received hormone therapy within 6 months, or have obvious symptoms of infection; (7) Refusal to sign informed consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CD3+T lymphocyte percentage; | — |
Secondary
| Measure | Time frame |
|---|---|
| T4 lymphocyte percentage;T8 lymphocyte percentage;CD4/CD8 lymphocyte subgroup ratio;B lymphocyte percentage;NK cell percentage;Postoperative pain VAS score and analgesic remedy use;Pulmonary complications;Regional lymph node metastasis, local recurrence, or distant metastasis within 2 years after surgery;CRP ;TNF-a ;IL-6; Sleep quality score ;and postoperative recovery quality within 30 days after surgery; | — |
Countries
China
Contacts
Public ContactChao Li
The Fourth Hospital of Hebei Medical University
Outcome results
None listed