mild cognitive impairment
Conditions
Interventions
Exposed group (With insomnia disorder):None
Non-exposed group (Without insomnia disorder):None
Sponsors
Beijing Anding Hospital
Eligibility
Sex/Gender
All
Age
55 Years to 100 Years
Inclusion criteria
Inclusion criteria: ? Provide written informed consent; ? Age =55 years old; (3) The chief complaint of memory impairment, provided by the patient himself, his family or an insider; (4) Memory impairment was not consistent with age and education level (clinical memory scale score was lower than 1.5 SD of age and education level matching norm); (5) Normal daily living ability, that is, daily living ability Rating Scale (ADL) =100 points; ? Hachinski Ischemia Index scale score < 4; ? Education level above primary school; The course of MCI is =3 years.
Exclusion criteria
Exclusion criteria: Previous or current DSM-5 diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, Alzheimer's disease, other causes of secondary dementia and other psychiatric disorders; Have other serious physical diseases such as cardiovascular, liver, kidney, respiratory system, endocrine system, nervous system or blood system diseases; ? severe aphasia, visual and hearing impairment, etc., can not complete the scale assessment; A history of alcohol dependence and other psychoactive substance abuse (e.g. antipsychotics, benzodiazepines).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Conversion rate of MCI to AD at study end point (3 years);; | — |
Secondary
| Measure | Time frame |
|---|---|
| The change values of cognitive scores from baseline at different visiting points: MMSE, MoCA, ADL, AVLT, SDMT, VFT, BNT, HAMD-17, HAMA;Change in neuroimaging measures from baseline: bilateral hippocampal volume, total gray and white matter volume, white matter hypersignal;Changes of sleep indicators from baseline: PSQI, Epworth sleepiness Scale, sleep duration, PSG parameters (sleep duration, sleep quality, etc.), neuroelectrophysiological indicators; | — |
Countries
China
Contacts
Public ContactQinge Zhang
Beijing Anding Hospital
Outcome results
None listed