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A randomized controlled trial of sequential treatment by sclerotherapy and microwave ablation versus microwave ablation of large predominantly cystic thyroid nodules

A randomized controlled trial of sequential treatment by sclerotherapy and microwave ablation versus microwave ablation of large predominantly cystic thyroid nodules

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400081445
Enrollment
Unknown
Registered
2024-03-01
Start date
2024-03-01
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid Nodules

Interventions

PS-MWA group:Sequential treatment by sclerosis-microwave ablation, MWA treatment was performed 1-2 months later
MWA group:Microwave ablation treatment

Sponsors

The Third Affiliated Hospital of Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1) Age = 18 years old; 2) Cystic predominant thyroid nodules (cystic component 50-90%) : nodule volume =10ml or diameter =4cm, and larger cystic cavity diameter =2cm. 3) Patients with compression symptoms or cosmetic problems. 4) Cystic predominant thyroid nodules were cytologically or histological considered benign nodules. 5) Normal thyroid function. 6) The informed consent has been signed.

Exclusion criteria

Exclusion criteria: 1) Allergy to the contrast medium SonoVue. 2) Severe cardiopulmonary and pulmonary dysfunction. 3) Severe coagulation dysfunction. 4) Pregnancy status. 5) There are physical and psychological obstacles to cooperate with local anesthesia operation. 6) The presence of coarse calcification in the lesion affected the observation.

Design outcomes

Primary

MeasureTime frame
Volume reduction ratio (3M);

Secondary

MeasureTime frame
Operation time of MWA ablation;Incidence of complications;Volume reduction ratio (1M,6M,12M);Cosmetic score;Symptom score;Complete ablation rate;

Countries

China

Contacts

Public ContactTao Wu

The Third Affiliated Hospital of Sun Yat-sen University

wutao22@mail.sysu.edu.cn+86 135 6033 2786

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026