Postoperative delirium
Conditions
Interventions
Intranasally administered insulin(INI) group:Intranasal insulin (INI) administration, at a dosage of 0.5 ml containing 20 IU
Control group:patients receiving a intranasally administered 0.5 ml injection of 0.9% normal saline.
Sponsors
Department of Anesthesiology, Xinqiao
Hospital of Chongqing, Second Afliated
Hospital of Army Medical University, PLA,
Chongqing 400037, China
Eligibility
Sex/Gender
All
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 45-65 years scheduled for elective cardiac surgery 2. Capable of engaging in concise communication with the investigator and successfully conducting the assessment using relevant scales 3. Mini-Mental Status Examination (MMSE) score greater than 17 4. Willing to participate in this study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. ASA I-III 2. Allergy to insulin 3. BMI > 35 kg/m2 4. History of mental illness or taking psychotropic drugs 5. Combined with diabetes 6. Combined with cerebral infarction or stroke 7. Long-term use of analgesics or sedatives 8. History of drug abuse, alcohol or opioid abuse 9. Chronic pain or recent acute pain 10. Contraindicated for nasal administration 11. Participants retain the right to withdraw from the study at their discretion for any reason, or if researchers deem their inclusion in the trial inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium (within 4 days); | — |
Secondary
| Measure | Time frame |
|---|---|
| duration of Intensice Care Unit (ICU);postoperative hospital length of stay;all in-hospital mortality;the change in MMSE scores pre- and post-operation;incidence of postoperative cognitive dysfunction at 1 month;incidence of postoperative cognitive dysfunction at 3 month;incidence of postoperative cognitive dysfunction at 6 month; | — |
Countries
China
Contacts
Public ContactGuiying Yang
Department of Anesthesiology, Xinqiao Hospital of Chongqing, Second Afliated Hospital of Army Medical University, PLA, Chongqing 400037, China
Outcome results
None listed