Procedural sedation
Conditions
Interventions
Chloral hydrate enema group:Chloral hydrate with different routes of administration
Chloral hydrate oral group:Chloral hydrate with different routes of administration
Sponsors
Department of Anesthesiology, Hunan Children's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Children undergoing procedural sedation within 0-3 months (guardians must sign the guardian version of the informed consent form)
Exclusion criteria
Exclusion criteria: (1) Allergy to the components of chloral hydrate enema. (2) Current concomitant with any of the following diseases: ? Diarrhea or anorectal disease that may affect drug absorption in the opinion of the investigator ? Intracranial hypertension ? Central apnea ? Respiratory neuromuscular disease ? Acute respiratory failure ? Obstructive sleep apnea syndrome ? Proctitis or colitis • Brain herniation ? Severe hepatic/renal insufficiency (ALT or AST> 5 times the upper limit of normal, or bilirubin > 2.5 times the upper limit of normal; SCr >176 µmol/L)? Severe cardiovascular disease (e.g., fulminant myocarditis, high- or third-degree atrioventricular block, sick sinus syndrome, hemodynamically unstable arrhythmia, cardiomyopathy, high pulmonary hypertension, pulmonary atresia, heart failure) ? Porphyria • Mitochondrial disease • Convulsions due to hypoglycemia, electrolyte imbalances, toxicity, liver failure, or hypertensive encephalopathy (3) Life expectancy of < 14 days due to imminent termination of life support or severity of illness. (4) There are other factors that the investigator considers unsuitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The original reflex returns to a 2-point horizontal time.; | — |
Countries
China
Contacts
Public ContactWu Wei
Hunan Children's Hospital
Outcome results
None listed