Obesity
Conditions
Interventions
Control group:Conventional lifestyle
Intensive comprehensive intervention group:Integrated online and offline lifestyle interventions (including diet, exercise, behavior, and psychology)
Low-carbohydrate diet intervention group:Intervention of low-carbohydrate diet with carbohydrate content accounting for 35% under the guidance of nutritionists.
Nutritional replacement diet intervention group:Provide standard food nutrition substitute products and dietary guidance under the guidance of nutritionists.
Exercise intervention group:According to the physical fitness, age, exercise habits, work, BMI and other factors of the patients, the exercise experts make a reasonable exercise plan.
Personalized intervention group:Individualized intervention prescription was formulated according to the patients situation, and lifestyle, exercise and diet intervention were combined under the guida
Drug treatment group:Smeaglutide injection for type 2 diabetes patients with obesity
Drug treatment control group:Type 2 diabetes patients with obesity were treated with comprehensive lifestyle intervention (healthy diet, exercise, behavior and psychology).
Sponsors
Xi’an Jiaotong University International Obesity and Metabolic Diseases Research Center
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) 28=BMI=40 kg/m2 (pharmacotherapy: 28=BMI=40 kg/m2 with type 2 diabetes) 2) 18 years=age <60 years, regardless of gender 3) Good adherence to follow-up, with a follow-up duration of =3 months 4) Voluntary participation in the study
Exclusion criteria
Exclusion criteria: 1) Pregnant or lactating women 2) Reported weight change exceeding 5% in the past three months 3) History of bariatric surgery 4) Participation in other clinical trials in the last 3 months 5) Planned changes in lifestyle (physical exercise, diet, etc.) in the next 3 months 6) Venereal diseases or other communicable diseases in active stage, including viral hepatitis, HIV/AIDS, syphilis, tuberculosis, etc. 7) Vegetarians 8) Significant untreated mental disorders, including bulimia and anorexia nervosa 9) Use of anti-obesity medications in the past 3 months or current use of known weight-affecting medications (e.g., corticosteroids) 10) Previous or present history of pancreatitis or other pancreatic diseases 11) History or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN-2) 12) Patients judged by the investigator as unsuitable for study participation, e.g., those with severe chronic diseases (e.g., diabetic ketoacidosis, myocardial infarction, stroke, or cancer) 13) Patients judged by the investigator as likely to hinder study adherence
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body mass index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Waist circumference;Blood pressure;Blood glucose;Blood fat;Body fat percentage;Behaviors;Renal function;Liver function; | — |
Countries
China
Contacts
Public ContactYoufa Wang
Xi’an Jiaotong University International Obesity and Metabolic Diseases Research Center
Outcome results
None listed