breast cancer
Conditions
Interventions
Normal opioid group (group C, control group):Under general anesthesia. Induction dose: Midazolam 0.05 mg/kg, propofol 1-2 mg/kg and cisatracurium 0.15 mg/kg. After induction, 20ml of 0.5% ropivacaine
no opioid group (group F, experimental group):Under general anesthesia, 0.3mg/kg of esketamine was administered intravenically 10 minutes before induction. Induction dose: Midazolam 0.05 mg/kg, propof
Sponsors
Liu Xuesheng
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients undergoing modified radical mastectomy under general anesthesia, communication normal, signed informed consent, ages 18-65, female.
Exclusion criteria
Exclusion criteria: ? preoperative hearing impairment, consciousness impairment or mental illness (Glasgow score =14 points); ? any known allergy to the investigational drug; ? Obesity (BMI>30kg/?); Coagulation dysfunction, severe respiratory and circulatory diseases, injection site infection; (5) Patients who received preoperative radiotherapy and chemotherapy, long-term oral sedatives, preoperative pain and need preoperative analgesics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3 days after surgery, QOR-15 scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Preoperative and postoperative heart rate (HR);Resting and exercise VAS scores at 2 days after surgery;Restlessness score during convalescence;Postoperative complication: nausea;Mean preoperative and postoperative arterial pressure (MAP);Postoperative discharge time;Postoperative complication: vomiting;Postoperative complication: bradycardia;Postoperative complication: hypotension;Postoperative complication: dizziness;Postoperative complication: upper limb edema; | — |
Countries
China
Contacts
Public ContactLiu Xuesheng
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed