Respiratory disease in children
Conditions
Interventions
Sponsors
Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1) Male or female children aged 29 days to 18 years; 2) Hospitalized in the Respiratory Department of Shanghai Children's Medical Centre from March 2024 to February 2025; 3) Clinical diagnosis of lower respiratory tract infection including bronchitis, bronchiolitis or pneumonia; 4) Acute respiratory distress (acute respiratory distress is defined as shortness of breath (< 2 months: = 60 breaths/min; 2-12 months: = 50 breaths/min; 1-5 years: = 40 breaths/min; = 5 years: = 30 breaths/min) with assisted respiratory muscle movements, including a positive triple-concave sign), with oxygen administered through nasal cannula (2 L/min) or mask (5 L/min), and still having respiratory distress, and the patients were considered to be in need of HFNC treatment by a physician of respiratory speciality or above; 5) Informed consent for the study was obtained from the legal guardians of the children (children over 8 years of age were also required to give their informed consent).
Exclusion criteria
Exclusion criteria: 1) Cardiac or respiratory arrest; 2) Glasgow score of 50 mmHg); 5) Imaging suggests the presence of pneumothorax and airway foreign body signs; 6) The child is unable to co-operate with HFNC treatment; 7) The investigator considers the subject to be potentially at risk or has any other factor that interferes with the subject's ability to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HFNC treatment failure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical respiratory score, CRS;Pediatric early warning score,PEWS; | — |
Countries
China
Contacts
Public ContactJing Zhang
Department of Respiratory, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed