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Efficacy of pain reprocessing therapy (PRT) in adults with chronic widespread pain: A pilot randomized clinical trial

Efficacy of pain reprocessing therapy (PRT) in adults with chronic widespread pain: A pilot randomized clinical trial - Efficacy of pain reprocessing therapy (PRT) in adults with chronic widespread pain

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400081418
Enrollment
Unknown
Registered
2024-02-29
Start date
2024-03-01
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Widespread Pain

Interventions

and 5) gravitating to positive feelings and sensations.
Pain Reprocessing Therapy group :Participants receiving PRT treatment will be given individual 1-hour therapy sessions with a PRT therapist once per week for 8 weeks. PRT has five main components: 1)
2) gathering and reinforcing personalized evidence for the brain origins and reversibility of pain
3) attending to and appraising pain sensations through a lens of safety
4) addressing other emotional threats
Control group:Patients in the control group will be asked to continue their routine GOPCs appointments. They will also be given psychoeducation sessions in groups bi-weekly for a total of 4 sessions,
(ii) cognitive approaches
(iii) approaches to increase activity and (iv) relaxation training and relapse prevention.

Sponsors

The Chinese University of Hong Kong
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Subjects have to be aged = 18, with the report of musculoskeletal pain in at least 4 of 5 body regions and in at least 3 or more body quadrants (as defined by upper–lower/left–right side of the body) and axial skeleton (neck, back, chest, and abdomen), with pain duration of more than 3 months. A Widespread Pain Index (WPI) will be generated based on the number of pain sites. Subgroup of patients with fibromyalgia will be identified according to The American College of Rheumatology 2016 when subjects have a WPI of = 7 and a symptom severity scale (SSS) score of = 5 or a WPI between 4 and 6 and an SSS score of = 9. The counselling assistant will also perform a one-hour session individually with each of the screened CWP participants to confirm the eligibility of the participants.

Exclusion criteria

Exclusion criteria: Exclusion criteria include major chronic illnesses, such as malignancy, active inflammatory diseases, autoimmune diseases and metabolic diseases such as diabetes mellitus and thyroid diseases, use of antibiotics, probiotics or prebiotics in the preceding 2 months, any acute illness in the preceding month, change in regularly taken medication in the preceding month, and substantial dietary alterations in the preceding month.

Design outcomes

Primary

MeasureTime frame
Brief Pain Inventory - Severity score (BPI-S);

Secondary

MeasureTime frame
Brief Pain Inventory - Interference score (BPI-I);Pressure Pain Thresholds, Tender Point Counts, Total Myalgic Score;Kinesiophobia;Physical activity level;Self-efficacy of pain management;Level of anxiety and depression;Fatigue;Overall health-related quality of life;

Countries

China

Contacts

Public ContactProf. Regina Wing Shan SIT

The Chinese University of Hong Kong

reginasit@cuhk.edu.hk+852 2252 8452

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026