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Preventive effect of lactulose on adverse events after colorectal endoscopic submucosal dissection: a randomized controlled clinical study

Preventive effect of lactulose on adverse events after colorectal endoscopic submucosal dissection: a randomized controlled clinical study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400081412
Enrollment
Unknown
Registered
2024-02-29
Start date
2024-03-01
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intestinal polyp

Interventions

Lactulose group:After ESD, patients were routinely given lactulose,10-30ml QD Po (the specific dose depends on the stool condition, to keep the soft stool unobvious) for 7 days
Control group:No lactulose after ESD

Sponsors

the Second Clinical Medical College of Jinan University (Shenzhen People's Hospital)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.18-80 years old, male or female; 2.Patients with ESD adaptation (colorectal lateral polyp with a diameter of 2cm) who accepted ESD treatment; 3. Sign the informed consent; 4. Complete resection was confirmed by postoperative patholog.

Exclusion criteria

Exclusion criteria: 1.Patients who do not meet the signs of colorectal ESD; 2. Patients with abnormal colorectal anatomy and unable to complete endoscopic surgery; 3 Complicated with severe heart, lung, brain or kidney disease; 4.Abnormal coagulation function; 5. Patients with other clear causes of infection, fever and elevated WBC; 6 Allergic to drug ingredients; Pregnant and lactating women.

Design outcomes

Primary

MeasureTime frame
Bleeding;Perforation;Abdominal pain;Fever;Elevated white blood cells;

Secondary

MeasureTime frame
Complete resection;En bloc resection;R0 resection;Resection operation time;

Countries

China

Contacts

Public ContactLi-sheng Wang

the Second Clinical Medical College of Jinan University (Shenzhen People's Hospital)

wanglsszrmyy@163.com+86 137 1472 5662

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026