Cardiovascular metabolic disorders
Conditions
Interventions
Combination therapy with semaglutide treatment.:NA
Sponsors
First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 78 Years
Inclusion criteria
Inclusion criteria: 1.Fully understand the purpose and requirements of this study, sign the informed consent form, and exhibit good compliance. 2.Patients meeting the following criteria: a. Obesity or overweight individuals aged =18 years: BMI = 23 kg/m^2 (Asian criteria) Abdominal obesity: Male waist circumference = 90 cm or female = 85 cm, waist-to-hip ratio = 1.0 b. Patients with comorbidities such as hypertension, diabetes or impaired glucose tolerance, insulin resistance, hyperlipidemia, hyperuricemia, and hyperhomocysteinemia. 3.History of, currently receiving, or voluntarily requesting treatment with semaglutide.
Exclusion criteria
Exclusion criteria: 1. Contraindications for the use of semaglutide include conditions such as medullary thyroid carcinoma in patients with multiple endocrine neoplasia syndrome type 2. 2. Patients with a history of allergy to GLP-1 analogs. 3. Active enteritis or gastritis; gastrointestinal ulcers or bleeding; post-gastrointestinal surgery. 4. Pregnancy or lactation. 5. Other malignant diseases affecting patient survival, such as severe autoimmune diseases. 6. Special dietary habits, such as vegetarianism. 7. Situations where the investigator deems recruitment inappropriate. 8. Patients currently participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body Weight;BMI;Waist circumference,;waist-to-hip ratio;systolic blood pressure;diastolic blood pressure;fasting blood glucose;2-hour postprandial blood glucose;glycated hemoglobin;total cholesterol;triglycerides;low-density lipoprotein;high-density lipoprotein;uric acid;Homocysteine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to achieve 5% and 10% weight loss from the start of treatment;MACE; | — |
Countries
China
Contacts
Public ContactAilan Chen
Datansha Campus, The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed