Adolescent emotional and behavioral disorders(Schizophrenia, Depression, Bipolar disorder)
Conditions
Interventions
Schizophrenia group:Selecte one of the three antipsychotic drugs for treatment: risperidone, aripiprazole and olanzapine
Depression group:Selecte a single antidepressant of SSRI for treatment
BD group:Selecte one of the three mood stabilizers for treatment: risperidone, aripiprazole and olanzapine
healthy controls:none
Common rTMS treatment group:Common rTMS treatment
Image navigation accurate rTMS treatment group:Image navigation accurate rTMS treatment
Sponsors
He'nan Mental Hosptial
Eligibility
Sex/Gender
All
Age
11 Years to 18 Years
Inclusion criteria
Inclusion criteria: SCZ inclusion criteria: 1. In the first acute stage of the disease, the duration of the disease is less than 3 years (the interval is not more than 6 months), which meets the DSM-5 diagnostic criteria of SCZ; 2. 11-18 years old, and at least one guardian shall monitor the patient within one year; 3. It is expected that there will be no problems such as relocation of residence, inconvenient transportation and difficulty in seeing a doctor during the whole study; 4. Obtain the informed consent from patients and guardians, and sign the informed consent form; 5. Selecte one of the three antipsychotic drugs for treatment: risperidone, aripiprazole and olanzapine. Depression inclusion criteria: 1. In the first acute stage of the disease, the duration of the disease is less than 3 years (the interval is not more than 6 months), which meets the DSM-5 diagnostic criteria of Depression; 2. 11-18 years old, and at least one guardian shall monitor the patient within one year; 3. It is expected that there will be no problems such as relocation of residence, inconvenient transportation and difficulty in seeing a doctor during the whole study; 4. Obtain the informed consent from patients and guardians, and sign the informed consent form; 5. Selecte a single antidepressant of SSRI for treatment. Bipolar Disorder inclusion criteria : 1. In the first acute stage of the disease, the duration of the disease is less than 3 years (the interval is not more than 6 months), which meets the DSM-5 diagnostic criteria of BD; 2. 11-18 years old, and at least one guardian shall monitor the patient within one year; 3. It is expected that there will be no problems such as relocation of residence, inconvenient transportation and difficulty in seeing a doctor during the whole study; 4. Obtain the informed consent from patients and guardians, and sign the informed consent form; 5. Selecte one of the three mood stabilizers for treatment: risperidone, aripiprazole and olanzapine. High-risk groups inclusion criteria: 1.Mild psychotic symptoms/short history of self-limited psychotic symptoms (self-resolution within 7 days)/positive family history of mental disorders and decreased social functioning; 2.No current physical illness; 3.11-18 years old, gender, education matched with patient groups; 4.Be able to cooperate with the completion of the project evaluation content; 5.Obtain the informed consent from patients and guardians, and sign the informed consent form; Healthy controls inclusion criteria: 1.Be in good health and have no mental illness meeting DSM-5 diagnostic criteria,screened for SCID; 2.No history of mental illness; 3.No current physical illness; 4.11-18 years old, gender, education matched with patient groups; 5. Be able to cooperate with the completion of the project evaluation content; 6.Obtain the informed consent from subjects and guardians, and sign the informed consent form; 7.No contraindication of magnetic resonance imaging (MRI).
Exclusion criteria
Exclusion criteria: SCZ/depression/BD patients exclusion criteria: 1.Serious somatic diseases or alcohol abuse; 2.Serious physical disability, unable to complete follow-up; 3.People suffering from other serious mental diseases, mental retardation, dementia and severe cognitive impairment; 4.Currently receiving or preparing to receive other clinical studies; High-risk groups exclusion criteria: 1.People with autism spectrum disorders; 2.Have a history of substance dependence; 3. Brain trauma, epilepsy or other organic brain diseases; 4. Laboratory examination shows liver and kidney function damage or other serious physical diseases and metabolic disorders; Healthy controls exclusion criteria: 1.Have a history of substance dependence; 2.Brain trauma, epilepsy or other organic brain diseases; 3.Have definite physical diseases such as hypertension and diabetes; 4.Laboratory examination shows liver and kidney function damage or other serious physical diseases and metabolic disorders; 5. Pregnant women or breast-feeding period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic evaluation;Adolescent behavioral and emotional assessment;Evaluation of psychiatric symptoms;Cognitive function assessment;Genetic Testing;Proteomic detection;Metabolomics detection;Neuroimaging detection;Neuroelectrophysiological tests; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reaction evaluation;Biochemical detection;Expressions, eye movements, language collection; | — |
Countries
China
Contacts
Public ContactLi Wenqiang
He'nan Mental Hospita, the Second Affiliated Hospital of Xinxiang Medical University
Outcome results
None listed