Simple vascular / lymphatic vessel malformation
Conditions
Interventions
Supine group:The anesthesiologist and family members work together to adjust the child's position so that the child is in a supine position with his head tilted backward. The plastic joint in the nebu
upright position group:The anesthesiologist and family members work together to adjust the child's position so that the child is upright and his head tilted backward. The plastic joint in the nebulize
intravenous administration group:The patients allocated to the intravenous administration group will receive 1 µg/kg of dexmedetomidine via intravenous infusion. The required dose of dexmedetomidine w
Sponsors
Guangzhou Women and Children's Medical Center
Eligibility
Sex/Gender
All
Age
2 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1. Children with simple vascular/lymphatic malformations classified according to the International Society for the Study of Vascular Malformations (Milwaukee, WI) standard classification and requiring interventional surgery under general anesthesia; 2.Age 2-6 years old; 3.The American Society of Anesthesiologists (ASA) assessment level is level I-III;
Exclusion criteria
Exclusion criteria: 1. Premature infants or children with severe growth and development delay; 2. Have a history of allergy or hypersensitivity to dexmedetomidine; 3. Severe heart, liver, and kidney dysfunction; 4. Have used dexmedetomidine or any other sedative within one week; 5. Active respiratory symptoms, runny nose, vascular malformation and other symptoms in or near the nasal cavity that may affect nasal drug absorption; 6. Nose bleeding, history of sinus surgery and severe nasal septum deviation;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pharmacokinetic parameters of two different postural administration methods; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedation success rate (UMSS = 2);Time to fall asleep;Time to wake up ;Incidence of adverse events; | — |
Countries
China
Contacts
Public ContactBilian Li
Guangzhou Women and Children's Medical Center
Outcome results
None listed