Labor Pain
Conditions
Interventions
Sufentanil group:Sufentanil 0.3ug/ml
Esketamine group:Esketamine 0.5mg/ml
Sponsors
Obstetrics and Gynecology Hospital Affiliated to Zhejiang University School of Medicine
Eligibility
Sex/Gender
Female
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Parturients aged 20-50 years with ASA II, BMI 18.5-30,healthy singleton pregnancies at term (=37 weeks gestational age), spontaneous onset of labor, latent phase of labor with cervical dilation of 2–5 cm, and painful contractions requiring labor epidural analgesia, without electrolyte disorders as well as infectious, immunologic, Endocrine system diseases.
Exclusion criteria
Exclusion criteria: parturients suffering from psychiatric and central nervous system disorders, liver disease, renal function abnormalities, cardiopulmonary function abnormalities, diabetes mellitus;severe obstetric comorbidities and complications such as pre-eclampsia and eclampsia, hyperemesis gravidarum, placenta previa, placenta previa; stillbirth; neonatal malformation; Contraindications to the use of esketamine exist (e.g., hypertension, tachycardia, hypersensitivity to esketamine and its components, etc.);Parturients with contraindications to neuraxial anesthesia; abnormal coagulation function; recent use of cardiovascular drugs, sedative and analgesic drugs, hormonal drugs, anti-psychotic drugs and anticoagulant drugs; severe hypovolemia and hemodynamic instability, as well as refusing to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EC50 of ropivacaine in each group; | — |
Secondary
| Measure | Time frame |
|---|---|
| EC95 of ropivacaine in each group;Total ropivacaine consumption in each group;The total number of PCEA boluses;Durations of labour;Mode of delivery;Bromage score;The NRS score of maternal pain;The Ramsay sedation scale score;Mean arterial pressure, heart rate and SpO2 of each parturient;Neonatal Apgar score assessed at 1 and 5 minutes after birth;The incidence of adverse events; | — |
Countries
China
Contacts
Public ContactLili Xu
Obstetrics and Gynecology Hospital Affiliated to Zhejiang University School of Medicine
Outcome results
None listed