Postoperative cognitive dysfunction
Conditions
Interventions
rTMS group:rTMS treatment+Conventional perioperative management
Pseudo-rTMS group:pseudo-rTMS treatment+Conventional perioperative management
Sponsors
Shanghai Fourth People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age = 60 years, male or female; 2. Need to perform TKA surgical treatment due to knee osteoarthritis; 3. Normal cognition, speech and hearing, able to cooperate with rehabilitation assessment and rehabilitation therapy; 4. Vital signs are stable;
Exclusion criteria
Exclusion criteria: 1. Drug allergy, severe cardiovascular disease, liver and kidney dysfunction; 2. Preoperative history of long-term use of antidepressants or tranquillisers; 3. Those who have metal foreign bodies in the cranium and have significantly increased intracranial pressure; 4. Those with stents or pacemakers in the heart; 5. Patients with epilepsy; 6. People who have cochlear implants;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-Mental stare examination;Digital Breadth Test;Digital Symbol Test;Trace link test;Short Story Memory Test;Chinese reversion of confusion assessment method; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-1ß;IL-6;TNF-a;HMGB1; | — |
Countries
China
Contacts
Public ContactXiaohua Ke
Shanghai Fourth People's Hospital
Outcome results
None listed