respiratory system
Conditions
Interventions
First part:Collect relevant clinical data
Intervention group:Mechanical ventilation strategy with the lowest risk of lung injury
Control group:Their ventilation strategy was left at the discretion of the physician
Sponsors
Fujian Children's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: Children undergoing selective bronchial occlusion and one-lung ventilation thoracoscopic surgery; and age is less than 18 years old.
Exclusion criteria
Exclusion criteria: Part I: (1) The ASA rating is Grade III or above; (2) Intraoperative inhalation anesthesia or spinal anesthesia; (3) intraoperative blood transfusion or use of vasoactive drugs; (4) Preoperative pulmonary infection, atelectasis or heart, lung, liver and kidney insufficiency or other systemic diseases; (5) In the case of changing to double lung ventilation during operation, the surgical field of vision was affected by hypoxia (SPO2<90%), one lung ventilation or other reasons; (6) Incomplete clinical data. Part II: (1) The ASA rating is Grade III or above; (2) Patients with heart, lung, liver and renal insufficiency; (3) refusing to participate in research projects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Operation mode; Mean arterial blood pressure, heart rate, inhaled oxygen concentration, inspiratory peak pressure, tidal volume, positive end-expiratory pressure, plateau pressure, minute ventilation and respiratory frequency before one-lung ventilation, 30 minutes after one-lung ventilation and 30 minutes after one-lung ventilation; Blood gas analysis of PH value, oxygen and index, carbon dioxide partial pressure;;Blood routine; Serum levels of inflammatory cytokines such as CRP, TNF-a, IL-1ß, IL-6, IL-8 and IL-10.;Incidence of lung injury during operation and within three days after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Basic information of children: age, sex, weight, height, home address, parents' occupation, family annual income, etc.;Clinical features of children: main diseases, complications, family history, ASA classification, preoperative lung function, CT and chest X-ray and other imaging data.;Other pulmonary complications (such as pulmonary infection, pulmonary embolism, respiratory failure, etc.); | — |
Countries
China
Contacts
Public ContactZengchun Wang
Fujian Children's Hospital
Outcome results
None listed