Frontotemporal dementia.
Conditions
Interventions
NLR treatment group:Carry out 20 minutes of transcranial and transnasal NIR modulation daily, lasting for 4 weeks.
Control group:No stimulation, wear the device for 20 minutes daily, lasting for 4 weeks.
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Aged 45-70 years old; 2) Have cognitive impairment or behavioral disorders, and meet the diagnostic criteria of "possible bvFTD" in the 2011 International bvFTD Consortium diagnostic criteria; 3) Willing to participate in PET/MRI scans and clinical assessments; 4) Regular use of FTD-related medications, with no medication adjustments in the two months before enrollment and during the enrollment period. 5) Agree to participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Accurately differentiate other neurological diseases (such as Alzheimer's disease, Lewy body dementia, Parkinson's disease, cerebrovascular disease, epilepsy, encephalitis, normal pressure hydrocephalus, etc., which may affect cognitive function) based on clinical presentation, MRI, AV45-PET, and FDG-PET; 2) Have systemic diseases that may cause cognitive impairment (such as liver or kidney dysfunction, endocrine disorders, vitamin deficiencies, or tumors), or meet the criteria for DSM-IV depression and schizophrenia patients; 3) History of severe head trauma or prior craniotomy; 4) History of alcohol or substance abuse; 5) Unable to cooperate with imaging examinations, with contraindications for PET imaging, such as patients with pacemakers, implantable cardioverter defibrillators, implanted electronic systems, vascular clips, mechanical heart valves, or cochlear implants. 6) Adjustment of FTD-related medications within the past 2 months, leading to difficulty in determining whether the efficacy is due to medication adjustments or NIR treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychological assessment scales; | — |
Secondary
| Measure | Time frame |
|---|---|
| PET/MRI scan; | — |
Countries
China
Contacts
Public ContactLiyong Wu
Xuanwu Hospital, Capital Medical University
Outcome results
None listed