disorders of consciousness
Conditions
Interventions
VS group:Collect cranial MRI, EEG, fNIRS, and tDCS-EEG signals.
MCS- group:Collect cranial MRI, EEG, fNIRS, and tDCS-EEG signals.
MCS+ group:Collect cranial MRI, EEG, fNIRS, and tDCS-EEG signals.
HC group:Collect cranial MRI, EEG, fNIRS, and tDCS-EEG signals.
Sponsors
The Third Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
3 Years to 8 Years
Inclusion criteria
Inclusion criteria: The research subjects were pDOC children who received wake-up promoting therapy in our hospital. Inclusion criteria: ? Meets the pDOC diagnostic criteria; ? Between the ages of 3 and 8; ? Prior to the onset of pDOC, there were no congenital or hereditary neurological diseases such as cerebral palsy, epilepsy, and intellectual disability; ? No infectious diseases before relevant examination; ? The guardian agrees to participate in this study. The pDOC children included in this study will be classified according to the corresponding diagnostic criteria into vegetative state/unresponsive awakening syndrome (VS/UWS), micro conscious state+group (MCS+), and micro conscious state - group (MCS -). All pDOC children are required to receive standard CRS-R scores before MRI data collection. The data for healthy children comes from the Calgary Preschool Database in Canada: https://osf.io/axz5r/ . Or for pDOC children and healthy children who voluntarily participated in this study. The research plan has been approved by the Ethics Committee of the Third Affiliated Hospital of Zhengzhou University. Before conducting the examination, the guardians of all subjects were fully informed of the experimental purpose, methods, risks, and potential benefits, and the researchers provided detailed answers to their questions. Subsequently, they signed an informed consent form.
Exclusion criteria
Exclusion criteria: ? Failure to cooperate with data collection, resulting in incomplete data; ? The collected data does not meet the analysis criteria; ? Family members request to withdraw from this study; ? Researchers believe that it is necessary to withdraw from the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Node degree;Shortest path;Betweenness centrality;Small World attribute; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cortical gray matter volume of brain regions; | — |
Countries
China
Contacts
Public ContactDengna Zhu
The Third Affiliated Hospital of Zhengzhou University
Outcome results
None listed