robot-assisted radical prostatectomy
Conditions
Interventions
Conventional fixed PEEP group:After endotracheal intubation followed by a recruitment manoeuvre (RM), a positive end-expiratory pressure (PEEP) maintained at 5 cmH2O throughout the entire mechanical
Individualized PEEP group:Following endotracheal intubation, the initial recruitment manoeuvre followed by a decremental PEEP-titration trial will be performed. The minimum driving pressure will be re
Sponsors
Department of Anesthesiology, Chongqing University Cancer Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: ? Males undergoing robot-assisted laparoscopic radical prostatectomy; ? older than 18years; ? BMI < 30 kg/m2; ? Patients signed informed consent; ? Duration of surgery longer than 2 hours; ? Intermediate to high risk of postoperative pulmonary complications (ARISCAT score = 26]
Exclusion criteria
Exclusion criteria: ? A history of upper respiratory tract or pulmonary infection within the previous 4 weeks, ? Patients with severe cardiopulmonary diseases; ? Patients with atrial fibrillation; ? NYHA = III; ? Neuromuscular dysfunction; ? Intracranial hypertension; ? Glaucoma; ? Severe hypotension due to intra-operative hemorrhage or life-threatening complications; ? Conversion to open approach; ? Patients refused to participate in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation Index (PaO2/FiO2); | — |
Secondary
| Measure | Time frame |
|---|---|
| Peak airway pressure;plateau pressure;end-expiratory positive pressure;Driving pressure;Pulmonary compliance;mean arterial pressure;stroke volume variation;cardiac index;The diameter of optic nerve sheath ;Post-operative pulmonary complications; | — |
Countries
China
Contacts
Public ContactYan Jiang
Chongqing University Cancer Hospital
Outcome results
None listed